Emmy Award-nominated TWO AND A HALF MEN has been the #1 comedy on television for the past two seasons. It�s a comedy about men, women, sex, dating, divorce, mothers, single parenthood, sibling relations, surrogate families, money and, most importantly, love. More specifically, it's about the lives of two brothers, one brother's son and the many women who surround them. Charlie Harper (Charlie Sheen) is a well-to-do bachelor with a house at the beach, a Mercedes in the garage and an easy way with women. His casual Malibu lifestyle is interrupted when his tightly wound brother, Alan (Jon Cryer), and Alan's son, Jake (Angus T. Jones), come to stay with him. Complicating matters further are Charlie and Alan's narcissistic, emotionally toxic mother, Evelyn (Holland Taylor); Alan's deeply neurotic ex-wife, Judith (Marin Hinkle) and Charlie's domineering, unapologetically blue-collar housekeeper, Berta (Conchata Ferrell). Despite the complexities of their lives and their own strained relationship, Charlie and Alan have one thing in common--they both love Jake and want what's best for him. As a result, they manage to create a little family unit that promises to make each of them a better man.
from cbs.com
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| Charlie Sheen | ... | Charlie Harper (141 episodes, 2003-2009) |

| Jon Cryer | ... | Alan Harper (141 episodes, 2003-2009) |

| Angus T. Jones | ... | Jake Harper / ... (141 episodes, 2003-2009) |
 | Conchata Ferrell | ... | Berta (101 episodes, 2003-2009) |
 | Holland Taylor | ... | Evelyn Harper (67 episodes, 2003-2009) |
 | Marin Hinkle | ... | Judith Harper / ... (63 episodes, 2003-2009) |

| Melanie Lynskey | ... | Rose / ... (50 episodes, 2003-2009) |

| April Bowlby | ... | Kandi / ... (15 episodes, 2005-2007) |

| Jennifer Bini Taylor | ... | Chelsea / ... (14 episodes, 2003-2009) |
 | Ryan Stiles | ... | Dr. Herb Melnick / ... (13 episodes, 2004-2009) |

| Jane Lynch | ... | Dr. Linda Freeman (10 episodes, 2004-2009) |

| Emmanuelle Vaugier | ... | Mia (8 episodes, 2005-2009) |

| James Edson | ... | Stephan 'Bobby' Wasserstein / ... (7 episodes, 2004-2009) |

| J.D. Walsh | ... | Gordon / ... (7 episodes, 2004-2009) |

| Robert Wagner | ... | Teddy (5 episodes, 2007-2008) |

| Kelly Stables | ... | Melissa (5 episodes, 2008-2009) |

| Ming-Na | ... | Linda Harris / ... (4 episodes, 2007) |

| Rebecca McFarland | ... | Leanne (4 episodes, 2003-2007) |

| Robert Clotworthy | ... | TV Commercial Narrator / ... (4 episodes, 2006-2009) |
 | Kris Iyer | ... | Dr. Prajneep (3 episodes, 2004-2007) |

| Jenny McCarthy | ... | Courtney (3 episodes, 2007-2008) |

| Jeri Ryan | ... | Sherri (2 episodes, 2004-2005) |

| Kimberly Quinn | ... | Donna (2 episodes, 2007-2008) |

| Jenna Elfman | ... | Frankie (2 episodes, 2004) |

| Carol Kane | ... | Shelly (2 episodes, 2009) |

| Denise Richards | ... | Lisa (2 episodes, 2003-2004) |

| Sara Rue | ... | Naomi (2 episodes, 2006-2007) |

| Gail O'Grady | ... | Mandi (2 episodes, 2006) |
 | Martin Mull | ... | Russell (2 episodes, 2008-2009) |

| Steven Tyler | ... | Himself (2 episodes, 2003-2006) |

| Jodi Lyn O'Keefe | ... | Gail / ... (2 episodes, 2004-2005) |

| Juliette Goglia | ... | Joanie (2 episodes, 2004) |

| Katherine LaNasa | ... | Lydia (2 episodes, 2006) |

| Rachel Cannon | ... | Chloe / ... (2 episodes, 2006-2007) |

| Judy Greer | ... | Myra (2 episodes, 2007) |

| Steve Tom | ... | Minister (2 episodes, 2005-2008) |

| Carrie Reichenbach | ... | Alexis (2 episodes, 2008) |
 | Justin T. Milner | ... | Himself (2 episodes, 2003) |

| Nick Toth | ... | Football Announcer / ... (2 episodes, 2004-2005) |

| Brendan Patrick Connor | ... | Clive / ... (2 episodes, 2006-2008) |

| Susan Blakely | ... | Angie (2 episodes, 2008) |

| Joel Murray | ... | Petey (2 episodes, 2007-2009) |

| Michael Clarke Duncan | ... | Jerome / ... (2 episodes, 2008-2009) |

| Coby Ryan McLaughlin | ... | Jeremy (2 episodes, 2008) |

| Nicole Forester | ... | Camille / ... (2 episodes, 2004-2005) |
 | Tinashe Kachingwe | ... | Celeste Burnett (2 episodes, 2008-2009) |
 | Frankie J. Allison | ... | Rodney (2 episodes, 2003-2007) |
 | Eddie Gorodetsky | ... | Doug / ... (2 episodes, 2003-2009) |